Nolvadex is a medicine that influences your hormonal balance to prevent or treat certain diseases. It is most typically prescribed by doctors to prevent breast cancer in women due to its corrective effects on the estrogen balance. It is also used to treat breast cancer in both women and men. Nolvadex, which contains the drug Tamoxifen as the active substance, is also sometimes recommended to prevent osteoporosis (reduced bone density) in women after menopause. The medication is also prescribed to individuals suffering from the Albright syndrome, which is a genetic disorder characterized by an excessive production of several hormones, and Nolvadex helps with the management of some of its symptoms.
The biological mechanism of action of Tamoxifen is quite complicated as it has estrogen-blocking effects in some regions (breasts) while exerting the opposite, estrogen-like effects in other regions (bones, uterus). The detailed description of its complex influence on the body is beyond the scope of this article so discuss your concerns regarding Nolvadex effects with your doctor. Nolvadex (Tamoxifen) is categorized as a selective estrogen receptor modulator (SERM), which means that it has selective effects on the estrogen receptor, depending on its location in your body. For instance, it blocks estrogen receptors in the breasts, resulting in a protection against the effects of estrogen, which is helpful in diminishing the risk of breast cancer. The same effect is involved in the treatment of Albright syndrome, in which the patients suffer from the consequences of an excessive production of estrogen along with several other hormones due to genetic factors, and this imbalance can be at least in part corrected with Nolvadex intake. On the other hand, in the bone tissue, Tamoxifen has a mild stimulatory effect on the estrogen receptor (estrogen-like effect), which means that it mimics the action of estrogen naturally produced by the female body, but to a lesser degree. In other words, it acts as a “weaker” form of estrogen. In this case, the administration of Nolvadex (Tamoxifen) to women suffering from osteoporosis helps them compensate for the estrogen deficiency occuring after menopause. Since estrogen-like influences include a strengthening of the bones, Nolvadex is used frequently for this purpose.
Hormone-modulating treatments can be associated with a series of side effects since hormones play such a crucial role in our bodies and have diverse effects in many regions. Nolvadex (Tamoxifen) is no exception. Although you can easily find Nolvadex in Australia in pharmacies and specialized websites, it is highly necessary and even mandatory to undergo treatment only if your doctor recommends it. Adverse effects may include a slightly increased risk of uterine cancer due to the stimulatory (estrogen-like) effects exerted by Tamoxifen in this region, a higher risk of deep vein thrombosis, vision problems, pulmonary embolism, among others. Using Nolvadex during pregnancy is not recommended since it can exert a negative influence the development of the baby.
Nolvadex has proven itself effective in preventing breast cancer and improving bone health in postmenopausal women, which was demonstrated by several studies. Still, the decision to use it has to be made only after consulting with your doctor. Nolvadex therapy is prescribed by physicians when the positive effects outweigh the risk of adverse effects, which should be decided by your doctor after a medical evaluation.